| CAS NO: | 566-75-6 |
| 包装: | 1mg |
| 市场价: | 4410元 |
| Cas No. | 566-75-6 |
| Canonical SMILES | C[C@@]12[C@](CC([C@@H]2O)=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C=C4CC3 |
| 分子式 | C18H22O3 |
| 分子量 | 286.4 |
| 溶解度 | DMSO: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 16-Ketoestradiol is an active metabolite of the endogenous estrogen estrone .1It is formed from estroneviaan estriol or a 16-epiestriol intermediate by oxidation of the C-16 hydroxyl. 16-Ketoestradiol binds to estrogen receptor α (ERα) and ERβ with IC50values of 112.2 and 50.1 nM for the human receptors, respectively.2Intravaginal administration of 16-ketoestradiol increases vaginal epithelial thickness, stratification, and cornification in mice, indicating antiestrogenic activity.3 1.Brinton, L.A., Trabert, B., Anderson, G.L., et al.Serum estrogens and estrogen metabolites and endometrial cancer risk among postmenopausal womenCancer Epidemiol. Biomarkers Prev.25(7)1081-1089(2016) 2.Zhu, B.T., Han, G.-Z., Shim, J.-Y., et al.Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor α and β subtypes: Insights into the structural determinants favoring a differential subtype bindingEndocrinology147(9)4132-4150(2006) 3.Martin, L.Dimethylstilbestrol and 16-oxo-estradiol: Anti-estrogens or estrogens•Steroids13(1)1-10(1969) |
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