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16-Ketoestradiol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
16-Ketoestradiol图片
CAS NO:566-75-6
包装:1mg
市场价:4410元

产品介绍
An active metabolite of estrone
Cas No.566-75-6
Canonical SMILESC[C@@]12[C@](CC([C@@H]2O)=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C=C4CC3
分子式C18H22O3
分子量286.4
溶解度DMSO: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

16-Ketoestradiol is an active metabolite of the endogenous estrogen estrone .1It is formed from estroneviaan estriol or a 16-epiestriol intermediate by oxidation of the C-16 hydroxyl. 16-Ketoestradiol binds to estrogen receptor α (ERα) and ERβ with IC50values of 112.2 and 50.1 nM for the human receptors, respectively.2Intravaginal administration of 16-ketoestradiol increases vaginal epithelial thickness, stratification, and cornification in mice, indicating antiestrogenic activity.3

1.Brinton, L.A., Trabert, B., Anderson, G.L., et al.Serum estrogens and estrogen metabolites and endometrial cancer risk among postmenopausal womenCancer Epidemiol. Biomarkers Prev.25(7)1081-1089(2016) 2.Zhu, B.T., Han, G.-Z., Shim, J.-Y., et al.Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor α and β subtypes: Insights into the structural determinants favoring a differential subtype bindingEndocrinology147(9)4132-4150(2006) 3.Martin, L.Dimethylstilbestrol and 16-oxo-estradiol: Anti-estrogens or estrogens•Steroids13(1)1-10(1969)