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7-Methylguanosine-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7-Methylguanosine-d3图片
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of 7-methylguanosine
Canonical SMILESNC1=NC([O-])=C2[N+](C([2H])([2H])[2H])=CN([C@@]3([H])[C@H](O)[C@H](O)[C@@H](CO)O3)C2=N1
分子式C11H12D3N5O5
分子量300.3
溶解度0.1 M HCl: 10mg/mL,DMSO: 10mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7-Methylguanosine-d3is intended for use as an internal standard for the quantification of 7-methylguanosine by GC- or LC-MS. 7-Methylguanosine is a methylated form of the purine nucleoside guanosine . It is an RNA modification that is present in the 5’-terminal cap of mRNA, where it promotes translation, as well as in tRNA, where it stabilizes the tRNA structure.1,27-Methylguanosine has been used as a substrate to measure the activity of purine nucleoside phosphorylase (PNP).3Urinary 7-methylguanosine levels are decreased in patients with prostate cancer.1

1.FernÁndez-Peralbo, M.A., GÓmez-GÓmez, E., CalderÓn-Santiago, M., et al.Prostate cancer patients-negative biopsy controls discrimination by untargeted metabolomics analysis of urine by LC-QTOF: Upstream information on other omicsSci. Rep.638243(2016) 2.Tomikawa, C.7-Methylguanosine modifications in transfer RNA (tRNA)Int. J. Mol. Sci.19(12)4080(2018) 3.Stachelska-Wierzchowska, A., and Wierzchowski, J.Non-typical nucleoside analogs as fluorescent and fluorogenic indicators of purine-nucleoside phosphorylase activity in biological samplesAnal. Chim. Acta1139119-128(2020)