| CAS NO: | 220941-93-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 220941-93-5 |
| Canonical SMILES | FC1=CC=C2NC(CN3CCN(CC3)C4=CC=CC=N4)=CC2=C1 |
| 分子式 | C18H19FN4 |
| 分子量 | 310.4 |
| 溶解度 | DMSO: 31 mg/mL |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CP 226,269 is a dopamine D4receptor agonist.1It induces calcium flux in HEK293 cells co-expressing human dopamine D4, but not D2Lor D3, receptors and Gαqo5(EC50s = 32, >10,000, and 985 nM, respectively). CP 226,269 induces phospholipid methylation in SK-N-MC neuroblastoma cells, which endogenously express dopamine D1and D4receptors (EC50= 2.9 nM).2 1.Moreland, R.B., Nakane, M., Donnelly-Roberts, D., et al.Comparative pharmacology of human dopamine D2-like receptor stable cell lines coupled to calcium flux through Gqo5Biochem. Pharmacol.68(4)761-772(2004) 2.Sharma, A., Kramer, M.L., Wick, P.F., et al.D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophreniaMol. Psychiatry4(3)235-246(1999) |
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