| CAS NO: | 262433-54-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 262433-54-5 |
| Canonical SMILES | OC(C1=CC(F)=C(NC([C@H](O)C2=CC(C(C)(C)CCC3(C)C)=C3C=C2)=O)C=C1)=O |
| 分子式 | C23H26FNO4 |
| 分子量 | 399.5 |
| 溶解度 | DMSO: 20 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BMS 270394 is an agonist of retinoic acid receptor γ (RARγ; EC50= 30 nM in a transactivation assay) and the active enantiomer of BMS 189961 .1It is selective for RARγ over RARβ (EC50= 400 nM) and is inactive at RARα. BMS 270394 synergizes with paclitaxel to inhibit the growth of MCF-7 breast and OVCAR-3 ovarian cancer, as well as SqCC/Y1 head and neck squamous cell carcinoma, cells.2 1.Klaholz, B.P., Mitschler, A., Belema, M., et al.Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγProc. Natl. Acad. Sci. USA97(12)6322-6327(2000) 2.Vivat-Hannah, V., You, D., Rizzo, C., et al.Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel)Cancer Res.61(24)8703-8711(2001) |
m.cnreagent.com