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SABRAC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SABRAC图片
CAS NO:886212-98-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of acid ceramidase
Cas No.886212-98-2
Canonical SMILESBrCC(N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O)=O
分子式C20H40BrNO3
分子量422.4
溶解度Chloroform: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SABRAC is an inhibitor of acid ceramidase (IC50= 52 nM).1It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 µM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50=<1 µM), as well as induces accumulation of ceramides in the same cells. It completely inhibits anchorage-independent colony formation but does not induce cytotoxicity in PC3 MC cells when used at a concentration of 5 µM.

1.Camacho, L., Meca-CortÉs, O., Abad, J.L., et al.Acid ceramidase as a therapeutic target in metastatic prostate cancerJ. Lipid Res.54(5)1207-1220(2013)