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SenTraGor™ Cell Senescence Reagent
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SenTraGor™ Cell Senescence Reagent图片
CAS NO:2171036-89-6
包装与价格：
包装价格(元)
10mg电议
20mg电议
40mg电议
80mg电议

产品介绍
A cellular senescence detection reagent
Cas No.2171036-89-6
Canonical SMILESO=C(N1)N[C@](CS2)([H])[C@@]1([H])[C@@H]2CCCCC(OCC(C)(N3)NC4=CC=C(C5=C4C3=CC=C5)/N=N/C6=CC=C(/N=N/C7=CC=CC=C7)C8=C6C=CC=C8)=O
分子式C39H38N8O3S
分子量698.8
溶解度DMF: 2 mg/mL,DMSO: 2 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.3 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SenTraGor™ cell senescence reagent is a detection reagent for lipofuscin, a nondegradable lysosomal marker of cellular senescence.1It is composed of a Sudan Black B (SBB) derivative conjugated to biotin and can be detected using an anti-biotin antibody. SenTraGor™ cell senescence reagent has been used to detect lipofuscin accumulation in Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and primary non-small cell lung cancer (NSCLC) samples as well as soluble lipofuscin in serum from patients with various diseases, including dementia and rheumatoid arthritis.2,3,4

1.Evangelou, K., Lougiakis, N., Rizou, S.V., et al.Robust, universal biomarker assay to detect senescent cells in biological specimensAging Cell16(1)192-197(2017) 2.Evangelou, K., Veroutis, D., Paschalaki, K., et al.Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: Possible implications for viral mutagenesisEur. Respir. J.2102951(2022) 3.Giatromanolaki, A., Kouroupi, M., Balaska, K., et al.A novel lipofuscin-detecting marker of senescence relates with hypoxia, dysregulated autophagy and with poor prognosis in non-small-cell-lung cancerIn Vivo34(6)3187-3193(2020) 4.Rizou, S.V., Evangelou, K., Myrianthopoulos, V., et al.A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in FluidsCellular senescence: Methods and protocols. Methods in molecular biology 1896119-138(2019)