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MRT-14
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MRT-14图片
CAS NO:1263131-83-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
MRT-14 是 Smo 的有效拮抗剂。Smo 是参与 Hedgehog (Hh) 形态发生素信号转导的主要成分。MRT-14 具有研究与异常 Hh 信号传导相关的多种癌症的潜力。
Cas No.1263131-83-4
分子式C24H24N4O5
分子量448.47
溶解度DMSO : 100 mg/mL (222.98 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling[1].

[1]. Manetti F, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol. 2010;78(4):658-665.