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Notch 1 TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Notch 1 TFA (Notch homolog 1, translocation-associated) 可基因编码蛋白质 NOTCH 家族的成员。该 I 型跨膜蛋白家族成员具有共同的结构特征,包括由多个表皮生长因子样 (EGF) 重复序列组成的细胞外结构域和由多种不同结构域类型组成的细胞内结构域。
分子式C64H98N15F3O25S3
分子量1614.81
溶解度Water : 18.52 mg/mL (11.47 mM; ultrasonic and adjust pH to 9 with NaOH)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types[1].

Notch 1 is shown to promote mouse luminal prostate cell survival and proliferation through the activation of the prosurvival NF-κB pathway[2].Down-regulation of Notch 1 and Jagged1 in human prostate cancer cell lines decreases in vitro invasion and cell growth[2].

[1]. NOTCH1 notch receptor 1 [Homo sapiens (human)] Gene ID: 4851, updated on 28-Oct-2019.
[2]. Stoyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466.