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YAP/TAZ inhibitor-2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
YAP/TAZ inhibitor-2图片
CAS NO:2762617-31-0
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
YAP/TAZ inhibitor-2 是一种有效的具有口服活性的 TEAD-YAP/TAZ 抑制剂，EC50 值为 3 nM。YAP/TAZ inhibitor-2 显示出抗增殖活性。YAP/TAZ inhibitor-2 显示出抗肿瘤活性。
Cas No.2762617-31-0
分子式C19H14F4N4O
分子量390.33
溶解度DMSO : 100 mg/mL (256.19 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1].

YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC50 value of 5.33 nM in NCI-H226 cells[1].

YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)[1].

[1]. Xu, xiaofeng, et al. Bicyclic compounds, compositions and use thereof. WO2022037568A1.