5-HT3 antagonist 5

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5-HT3 antagonist 5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

901599-43-7

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议

产品介绍

5-HT3 antagonist 5 是一种喹喔啉 -2- 甲酰胺化合物，是 5-HT3 受体拮抗剂。5-HT3 antagonist 5 对 5-HT3 激动剂和 2- 甲基 -5-HT 也具有拮抗作用，并在小鼠中表现出抗抑郁效果。

Cas No.

901599-43-7

分子式

C₁₆H₁₃N₃O₂

分子量

279.29

溶解度

DMSO : 20.83 mg/mL (74.58 mM; ultrasonic and warming and heat to 60°C)

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a5-HT₃receptorantagonist. 5-HT3 antagonist 5 exerts antagonism on5-HT₃agonist and2-methyl-5-HT, and shows anti-depressant effect in mice^[1].

5-HT3 antagonist 5 (compound 4c) exhibits 5-HT₃receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT₃agonist, 2-methyl-5-HT, with pA₂value of 5^[1].

5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice^[1].

Animal Model:	Swiss albino mice (23 ± 2 g)^[1]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration
Result:	Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.