| CAS NO: | 301177-43-5 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 301177-43-5 |
| 分子式 | C20H23N3OS |
| 分子量 | 353.48 |
| 溶解度 | DMSO : 100 mg/mL (282.90 mM; ultrasonic and warming and heat to 60°C) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 8.4 μM (EPAC2)[1] ESI-08 is a potent and selectiveEPACantagonist, which can completely inhibit bothEPAC1andEPAC2(IC50of 8.4 μM) activity. ESI-08 selectively blocks cAMP-inducedEPACactivation, but does not inhibit cAMP-mediated PKA activation[1]. Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1]. |
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