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RKI 1447 dihydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RKI 1447 dihydrochloride图片
CAS NO:1782109-09-4
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
RKI 1447 dihydrochloride 是一种有效的选择性 ROCK 抑制剂，对 ROCK1 和 ROCK2 的 IC50 分别为 14.5 和 6.2 nM。 RKI 1447 dihydrochloride 抑制结直肠癌细胞生长并促进细胞凋亡。
Cas No.1782109-09-4
Canonical SMILESO=C(NCC3=CC=CC(O)=C3)NC1=NC(C2=CC=NC=C2)=CS1.Cl.Cl
分子式C16H14N4O2S.2HCl
分子量399.29
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective ROCK inhibitor (IC50 values are 6.2 and 14.5 nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells.

Patel et al (2012) RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 72 5025 PMID:22846914 |Pireddu et al (2013) Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2) Med.Chem.Comm. 3 699 PMID:23275831