| CAS NO: | 1166393-85-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 1166393-85-6 |
| Canonical SMILES | O=C(NC1=CC(COC2=CC=CN=C2)=NN1)NC3=CC(C(C)(C)C)=NN3C4=CC=C(C)C=C4 |
| 分子式 | C24H27N7O2 |
| 分子量 | 445.52 |
| 溶解度 | DMSO : 125 mg/mL (280.57 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2]. PF-4618433 (0.1-1.0 µM; 7 days) promotes osteogenesis of hMSC cultures. PF-4618433 increases in both alkaline phosphatase (ALP) activity and mineralization in a dependent manner[1].PF-4618433 (0.1-0.3 µM; 24 hours) enhances osteoblast proliferation[2].PF-4618433 (0.0125-0.3 µM; 14 or 21 days) enhances calcium deposition at the concentrations of 0.1 and 0.3 µM[2]. References: |
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