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DC-LC3in-D5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DC-LC3in-D5图片
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
DC-LC3in-D5 通过减弱 LC3B 脂化作用而作为自噬 (autophagy) 抑制剂。DC-LC3in-D5 与 LC3B 结合。DC-LC3in-D5 破坏 LC3B-LBP2 相互作用,IC50 为 200 nM。DC-LC3in-D5 可能通过抑制自噬有助于抗 HCV 或肿瘤的联合治疗。
分子式C19H22Cl2N2O3
分子量397.3
溶解度DMSO : 35.71 mg/mL (89.88 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination treatments in cancer through inhibiting autophagy[1].

DC-LC3in-D5 demonstrates high selectivity to LC3A/B in the proteome. DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells[1].Treatment of HeLa cells with DC-LC3in-D5 (3-30 μM) results in disruption of LC3B lipidation, inhibition of autophagic vesicle formation, and accumulation of p62[1].

[1]. Shijie Fan, et al. Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114.