Ethylene glycol monododecyl ether is a nonionic surfactant with a critical micelle concentration (CMC) of 27.5 µM at 25°C.¹It enhances the transdermal permeation of the antiemetic ondansetron across isolated porcine skin when used at a concentration of 160 mM, however, it decreases the viability of human epidermal keratinocytes and human dermal fibroblasts when used at a concentration of 160 µM.²

1.Islam, M.N., and Kato, T.Temperature dependence of the surface phase behavior and micelle formation of some nonionic surfactantsJ. Phys. Chem. B107(4)965-971(2003) 2.Silva, S.M.C., Hu, L., Sousa, J.J.S., et al.A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HClEur. J. Pharm. Biopharm.80(3)663-673(2012)