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WEE1-IN-5
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
WEE1-IN-5图片
CAS NO:2243882-74-6
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
WEE1-IN-5 是一种有效的 WEE1 抑制剂，IC50 为 0.8 nM。WEE1-IN-5 可抑制磷酸化 CDC2。WEE1-IN-5 消除 G2 检查点，增加癌细胞对 DNA 损伤剂 Carboplatin 的敏感性。WEE1-IN-5 可用于抗癌研究。$
Cas No.2243882-74-6
分子式C26H28Cl2N6O
分子量511.45
溶解度DMSO : 125 mg/mL (244.40 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

WEE1-IN-5 is a potentWEE1inhibitor with anIC50value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer[1].

WEE1-IN-5 exhibits an EC50of 188 nM in pCDC2 and an IC50shift for CYP3A4/5[1].

WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUCint1324 h.ng/mL and bioavailability of 35% in SD rats[1].