AZ13705339 hemihydrate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

AZ13705339 hemihydrate 是一种高效且具有选择性的 PAK1 抑制剂，对 PAK1 和 pPAK1 的 IC50 分别为 0.33 nM 和 59 nM。AZ13705339 hemihydrate 对 PAK1 和 PAK2 具有结合亲和力，Kd 分别为 0.28 nM 和 0.32 nM。AZ13705339 hemihydrate 可用于癌症研究。

分子式	C₃₃H₃₆FN₇O₃S.1/2H₂O
分子量	638.77
溶解度	DMSO : 100 mg/mL (156.55 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	AZ13705339 hemihydrate is a highly potent and selectivePAK1inhibitor withIC₅₀s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, withK_ds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers^[1]. AZ13705339 (1 μM) hemihydrate inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells^[2]. AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death^[3]. AZ13705339 hemihydrate (100 mg/kg, P.O.) has moderate clearance and oral C_maxof 7.7 μM in rats^[1].