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5,7-Dichlorothiazolo[5,4-d]pyrimidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5,7-Dichlorothiazolo[5,4-d]pyrimidine图片
CAS NO:13479-88-4
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
A building block
Cas No.13479-88-4
别名5,7-二氯噻唑并[5,4-D]嘧啶
Canonical SMILESClC1=NC(Cl)=C2N=CSC2=N1
分子式C5HCl2N3S
分子量206.1
溶解度DMF: 2 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5,7-Dichlorothiazolo[5,4-d]pyrimidine is a building block.1,2,3,4It has been used in the synthesis of a variety of compounds, including spleen tyrosine kinase (Syk), mammalian target of rapamycin (mTOR), and PI3Kδ inhibitors, as well as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with antiviral activity.

1.Lucas, M.C., Goldstein, D.M., Hermann, J.C., et al.Rational design of highly selective spleen tyrosine kinase inhibitorsJ. Med. Chem.55(23)10414-10423(2012) 2.Bonazzi, S., Goold, C.P., Gray, A., et al.Discovery of a brain-penetrant ATP-competitive inhibitor of the mechanistic target of rapamycin (mTOR) for CNS disordersJ. Med. Chem.63(3)1068-1083(2020) 3.Murray, J.M., Sweeney, Z.K., Chan, B.K., et al.Potent and highly selective benzimidazole inhibitors of PI3-kinase deltaJ. Med. Chem.55(17)7686-7695(2012) 4.Kang, D., Zhao, T., Wang, Z., et al.Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitorsCommun. Chem.274(2019)