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Clindamycin-d3(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clindamycin-d3(hydrochloride)图片
CAS NO:1356933-72-6
包装与价格:
包装价格(元)
500 µg电议
1mg电议

产品介绍
克林霉素-d3(盐酸盐)是氘标记的克林霉素。
Cas No.1356933-72-6
别名克林霉素-D3盐酸盐
Canonical SMILESO=C([C@@H]1C[C@H](CN1C([2H])([2H])[2H])CCC)N[C@@H]([C@@]2([H])O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C.Cl
分子式C18H30D3ClN2O5S ? HCl
分子量464.5
溶解度DMSO: soluble,Water: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Clindamycin-d3is intended for use as an internal standard for the quantification of clindamycin by GC- or LC-MS. Clindamycin is a lincosamide antibiotic.1,2It is active against Gram-positive bacteria, including various strains ofS. pneumoniae,S. viridans,S. aureus, andS. epidermidis(MICs = 0.002-0.1, 0.005-0.2, 0.04-1.6, and 0.1-0.2 µg/ml, respectively).1Clindamycin is also active against chloroquine-resistant and -sensitive strains ofP. falciparum(IC50s = 3.12 and 8.81 nM, respectively).2It inhibits bacterial protein synthesis by interacting with the 50S ribosome.1Clindamycin increases survival in a mouse model of a secondaryS. pneumoniaeinfection when administered at a dose of 15 mg/kg twice daily for seven days.3Formulations containing clindamycin have been used in the treatment of bacterial infections.

1.SpÍ?ek, J., and ?ezanka, T.Lincomycin, clindamycin and their applicationsAppl. Microbiol. Biotechnol.64(4)455-464(2004) 2.Dahl, E.L., and Rosenthal, P.J.Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplastAntimicrob. Agents Chemother.51(10)3485-3490(2007) 3.KarlstrÖm, Å., Boyd, K.L., English, B.K., et al.Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenzaJ. Infect. Dis.199(3)311-319(2009)