您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Cimpuciclib tosylate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Cimpuciclib tosylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cimpuciclib tosylate图片
CAS NO:2408872-84-2
包装:10mg
市场价:11250元

产品介绍
Cimpuciclib tosylate 是一种选择性的 CDK4 抑制剂 (IC50: 0.49 nM),具有抗肿瘤活性。
Cas No.2408872-84-2
分子式C37H43FN8O4S
分子量714.85
溶解度DMSO : 200 mg/mL (279.78 mM; Need ultrasonic)
储存条件4°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cimpuciclib tosylate is a selectiveCDK4inhibitor (IC50: 0.49 nM) that has anti-tumor activity[1].

Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells[1].

Cell Proliferation Assay[1]

Cell Line:Colo205 cells
Concentration:0-500 nM approximately
Incubation Time:6 days
Result:Inhibited cell proliferation with an IC50value of 141.2 nM.

Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma[1].

Animal Model:Colo205 tumor-bearing mice[1]
Dosage:50 mg/kg, twice a week
Administration:Oral gavage
Result:Inhibited tumor growth by 93.63%
Animal Model:Rats, colo205 tumor-bearing mice[1]
Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration:Oral administration
Result:Pharmacokinetic profile of Cimpuciclib (example 63).
doseCmax(ng/mL)Tmax(h)AUC0-24(ng/mL•h)t1/2(h)
5 mg/kg (rats)559.7654142.4
50 mg/kg (mice)7960113678214.8