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DDR1-IN-6
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DDR1-IN-6图片
CAS NO:2416021-47-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
DDR1-IN-6 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC50 为 9.72 nM。DDR1-IN-6 抑制 DDR1b (Y513) 自磷酸化，IC50 为 9.7 nM。DDR1-IN-6 具有抗癌活性。
Cas No.2416021-47-9
分子式C23H14F3N5O
分子量433.39
储存条件4°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DDR1-IN-6 is a selectiveDiscoidin Domain Receptor family, member 1 (DDR1)inhibitor with anIC50of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with anIC50of 9.7 nM. DDR1-IN-6 has anti-cancer activity[1].

DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=13 nM)[1].
DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC50=3 μM)[1].
DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC50=5.7 μM of 3 days; IC50=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC50>30 μM of 3 days; IC50>30 μM of 6 days)[1].