CVT-11127

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CVT-11127

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1018674-83-3

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议

产品介绍

CVT-11127 是一种有效的 SCD 抑制剂。CVT-11127 诱导细胞凋亡 apoposis 并将细胞周期阻滞在 G1/S 期。 CVT-11127具有肺癌研究潜力。

Cas No.

1018674-83-3

别名

GS-456332

分子式

C₂₅H₂₃Cl₂N₅O₃

分子量

512.39

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

CVT-11127 is a potentSCDinhibitor. CVT-11127 inducesapoposisand arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer^[1].

CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells^[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%^[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells^[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	H460 cells
Concentration:	1 µM
Incubation Time:	48 h
Result:	Showed antiproliferation activity.

Cell Cycle Analysis^[1]

Cell Line:	H460 cells
Concentration:	1 µM
Incubation Time:	48 h
Result:	Decreased the the population of cells in S-phase by 75%.

Apoptosis Analysis^[1]

Cell Line:	H460 cells
Concentration:	1 µM
Incubation Time:	24 h
Result:	Induced apoposis H460 cells.