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MDL 800
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:2275619-53-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An allosteric SIRT6 activator
Cas No.2275619-53-7
Canonical SMILESCC1=C(NS(C2=C(C(OC)=O)C=C(NS(C3=CC(Cl)=CC(Cl)=C3)(=O)=O)C=C2)(=O)=O)C=C(Br)C(F)=C1
分子式C21H16BrCl2FN2O6S2
分子量626.3
溶解度DMF: 10 mg/ml,DMSO: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MDL 800 is an allosteric activator of sirtuin 6 (SIRT6).1It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation (IC50= 23.3 µM) in, and reduces proliferation of, BEL-7405 hepatocellular carcinoma (HCC) cells (EC50= 90.4 µM). MDL 800 (0.1-5 µM) inhibits TNF-α release induced by oxygen and glucose deprivation (OGD) in primary mouse microglia.2In vivo, MDL 800 (50, 100, and 150 mg/kg) reduces tumor weight and volume in a BEL-7405 HCC mouse xenograft model.1

1.Huang, Z., Zhao, J., Deng, W., et al.Identification of a cellularly active SIRT6 allosteric activatorNat. Chem. Biol.14(12)1118-1126(2018) 2.He, T., Shang, J., Gao, C., et al.A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axisActa Pharm. Sin. B11(3)708-726(2021)