AFM-30a hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

AFM-30a hydrochloride 是一种有效的蛋白质精氨酸脱亚胺酶 2 (PAD2) 抑制剂，具有出色的 PAD2 选择性。AFM-30a hydrochloride 与 PAD2 结合的 EC50 值为 9.5 μM。AFM-30a hydrochloride 还抑制 H3 瓜氨酸化，EC50 值为 0.4 μM。AFM-30a hydrochloride 可用于某些癌症和多种自身免疫性疾病如类风湿性关节炎 (RA)、多发性硬化症、狼疮和溃疡性结肠炎的研究。

分子式

C₂₄H₂₈ClFN₆O₃

分子量

502.97

储存条件

4°C, away from moisture and light

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

AFM-30a hydrochloride is a potentprotein arginine deiminase 2 (PAD2)inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with anEC₅₀value of 9.5 μM. AFM-30a hydrochloride also inhibitsH3 citrullinationwith anEC₅₀value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis^[1].

AFM-30a hydrochloride (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC₅₀of 9.5 μM^[1].
AFM-30a hydrochloride shows good ability to inhibit H3 citrullination with an EC₅₀of 0.4 μM^[1].

Cell Viability Assay^[1]

Cell Line:	HEK293T/PAD2 cells
Concentration:	Various concentrations
Incubation Time:	24 h
Result:	Exhibited low cytotoxicity for cells.

AFM-30a hydrochloride suppresses NLRP3 signaling and decreases airway remodeling in PAD2^-/-transgenic mice^[2].