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NSC-87877 disodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NSC-87877 disodium图片
CAS NO:56932-43-5
包装:5mg
市场价:675元

产品介绍
NSC-87877 disodium 是一种有效的Shp2 和Shp1 蛋白质酪氨酸磷酸酶抑制剂，IC50 值分别为0.318 μM 和0.355 μM。NSC-87877还抑制双特异性磷酸酶26 (DUSP26)。
Cas No.56932-43-5
别名8-羟基-7-[(6-磺基-2-萘基)偶氮基]-5-喹啉磺酸二钠盐
分子式C19H11N3Na2O7S2
分子量503.42
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].

NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines[3].NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation[3].

NSC-87877 (30 mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].

[1]. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70.
[2]. Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.
[3]. Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841.