| CAS NO: | 391670-48-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 391670-48-7 |
| 别名 | 5,6-二氢-5-氧代吲哚并[1,2-A]喹唑啉-7-乙酸 |
| Canonical SMILES | O=C(CC(C1=C(N2C3=C4C=CC=C3)C=CC=C1)=C2NC4=O)O |
| 分子式 | C17H12N2O3 |
| 分子量 | 292.3 |
| 溶解度 | DMSO: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IQA is a casein kinase 2 (CK2) inhibitor (IC50= 0.39 µM).1IQA is selective for CK2 over protein kinase A (PKA), glycogen synthase kinase 3β (GSK3β), lymphocyte cell-specific protein tyrosine kinase (LCK), dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), and PI3Kγ (IC50s = 16, 14, 11, 8, and >200 µM, respectively). IQA decreases the viability of Jurkat leukemia cells in a concentration-dependent manner.2 1.Sarno, S., De Moliner, E., Ruzzene, M., et al.Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)Biochem. J.374639-646(2003) 2.Sarno, S., Ruzzene, M., Frascella, P., et al.Development and exploitation of CK2 inhibitorsMol. Cell. Biochem.274(1-2)69-76(2005) |
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