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IQA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IQA图片
CAS NO:391670-48-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A CK2 inhibitor
Cas No.391670-48-7
别名5,6-二氢-5-氧代吲哚并[1,2-A]喹唑啉-7-乙酸
Canonical SMILESO=C(CC(C1=C(N2C3=C4C=CC=C3)C=CC=C1)=C2NC4=O)O
分子式C17H12N2O3
分子量292.3
溶解度DMSO: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IQA is a casein kinase 2 (CK2) inhibitor (IC50= 0.39 µM).1IQA is selective for CK2 over protein kinase A (PKA), glycogen synthase kinase 3β (GSK3β), lymphocyte cell-specific protein tyrosine kinase (LCK), dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), and PI3Kγ (IC50s = 16, 14, 11, 8, and >200 µM, respectively). IQA decreases the viability of Jurkat leukemia cells in a concentration-dependent manner.2

1.Sarno, S., De Moliner, E., Ruzzene, M., et al.Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)Biochem. J.374639-646(2003) 2.Sarno, S., Ruzzene, M., Frascella, P., et al.Development and exploitation of CK2 inhibitorsMol. Cell. Biochem.274(1-2)69-76(2005)