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TP-021
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TP-021图片
CAS NO:2130878-25-8
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
TP-021 (BCL6-IN-8c) 是一种有效的具有口服活性的 BCL6-共抑制因子相互作用抑制剂，在无细胞酶联免疫吸附试验中，其 IC50 为 0.10 µM。
Cas No.2130878-25-8
别名BCL6-IN-8c
分子式C20H20ClN3O5
分子量417.84
溶解度DMSO : ≥ 50 mg/mL (119.66 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 0.10 µM (BCL6-corepressor interaction)[1]

TP-021 (BCL6-IN-8c) is a potent and orally activeB-cell lymphoma 6 (BCL6)-corepressor interactioninhibitor with anIC50of 0.10 µM in cell-free enzyme-linked immunosorbent assay[1].

TP-021 (BCL6-IN-8c, Compound 8c) also exhibits good cellular PPI inhibitory activity in the submicromolar range (M2H IC50= 0.72 µM). TP-021 (BCL6-IN-8c) does not exhibit significant cytotoxicity even at 30 µM[1].

The pharmacokinetic profile of TP-021 (BCL6-IN-8c, Compound 8c) is evaluated by a mouse cassette-dosing study (0.1 mg/kg iv; 1 mg/kg po). TP-021 (BCL6-IN-8c) exhibits a good pharmacokinetic profile (Cmax= 233 ng/mL, Tmax= 2 hours, MRT = 3.3 h, AUC = 1.27 mg•h/mL, F (oral bioavailability) = 79.9%)[1].