您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > MFI8
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
MFI8
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MFI8图片
CAS NO:694488-83-0
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
MFI8 是一种线粒体融合 (mitochondrial fusion) 的小分子抑制剂。
Cas No.694488-83-0
分子式C16H18ClNO
分子量275.77
溶解度DMSO : 100 mg/mL (362.62 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MFI8 is a small molecule inhibitor ofmitochondrial fusion[1].

MFI8 (20 μM; 6 h) reduces significantly mitochondrial aspect ratio with an EC50of 4.8 μM, and inhibits mitochondrial fusion via mitofusins and subsequently promoting mitochondrial fission[1].
MFI8 possesses functional groups that meet the criteria of the pharmacophore model to interact with mitofusins and promotes mitochondrial fission[1].
MFI8 binds to the HR2 domain of MFN2, modulates MFN conformation and complexes, and alters mitochondrial functionality[1].
MFI8 (0-20 μM; 6 h) concentration-responsively increases caspase-3/7 activity, induces cytochrome c release and decreases membrane potential in a mitofusin-dependent manner. MFI8 also induces DNA damage and induces cell death in combination with BV6 SMAC (second mitochondria-derived activator of caspases) mimetic[1].