Cathepsin C-IN-5

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Cathepsin C-IN-5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2825567-97-1

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议

产品介绍

Cathepsin C-IN-5 (compound SF38) 是一种有效的、选择性的和具有口服活性的组织蛋白酶 C 抑制剂，Cat C、Cat L、Cat S、Cat B、Cat K 的 IC50s 分别为 59.9 nM， 4.26 µM、>5 µM、>5 µM、>5 µM。Cathepsin C-IN-5 抑制骨髓和血液中的 Cat C 活性。Cathepsin C-IN-5 降低 NSP（中性粒细胞丝氨酸蛋白酶）的活化。Cathepsin C-IN-5 具有抗炎活性。

Cas No.

2825567-97-1

分子式

C₂₁H₁₇ClN₆OS

分子量

436.92

储存条件

4°C, away from moisture and light

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally activeCathepsin Cinhibitor withIC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity^[1].

Cathepsin C-IN-5 (compound SF38) shows inhibition in THP-1 and U937 cells with IC₅₀s of 115.4, 70.2 nM, respectively^[1].

Cathepsin C-IN-5 (1500 mg/kg) shows no significant weight loss or toxic reaction within 7 days after the administration in ICR mice^[1].
Cathepsin C-IN-5 (10 mg/kg for p.o.; 2 mg/kg for i.v.) shows good bioavailability with F=42.07%^[1].
Cathepsin C-IN-5 (2, 10, 50 mg/kg; p.o.) shows effective antiinflammatory activity and potential protective effect in an animal model of ALI^[1].

Animal Model:	C57BL/6 male mice (acute lung injury (ALI) mice model)^[1]
Dosage:	2, 10, 50 mg/kg (one hour after administration, received LPS (20 mg/kg))
Administration:	P.o.
Result:	Decreased the levels of proinflammatory cytokines (TNF-a, IL-6, and GM-CSF) and increased the the concentration of the anti-inflammatory cytokine (IL-10) in a dose-dependent manner.