Fendiline HCl is a potent acid sphingomyelinase (ASM) inhibitor, reducing the phosphatidylserine (PtdSer) and cholesterol content of the inner plasma membrane and inhibiting calcium function in muscle cells in excitation-contraction coupling. References: van der Hoeven D, Cho KJ, Zhou Y, Ma X, Chen W, Naji A, Montufar-Solis D, Zuo Y, Kovar SE, Levental KR, Frost JA, van der Hoeven R, Hancock JF. Sphingomyelin metabolism is a regulator of KRAS function. Mol Cell Biol. 2017 Nov 20. pii: MCB.00373-17. doi: 10.1128/MCB.00373-17. [Epub ahead of print] PubMed PMID: 29158292; PubMed Central PMCID: PMC5770534.

纯度：≥98%

CAS：13636-18-5