CI-966 is a central nervous system depressant acting as a GABA reuptake inhibitor, specifically a highly potent and selective blocker of the GABA transporter 1 (GAT-1) (IC50 = 0.26 μM). It has potential as an anticonvulsant, anxiolytic, and neuroprotective therapeutic agent. In a phase I human clinical trial it was developed for the treatment of epilepsy. References: Phillis JW. CI-966, a GABA uptake inhibitor, antagonizes ischemia-induced neuronal degeneration in the gerbil. Gen Pharmacol. 1995 Sep;26(5):1061-4. PubMed PMID: 7557251.

纯度：≥98%

CAS：110283-79-9