CMI-977, also know as LPD-977 and MLN-977, is a potent 5-lipoxygenase inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. CMI-977 inhibits the 5-lipoxygenase (5-LO) cellular inflammation pathway to block the generation of leukotrienes, which play a key role in triggering bronchial asthma. References: Ramsden AE, Mota LJ, Münter S, Shorte SL, Holden DW. The SPI-2 type III secretion system restricts motility of Salmonella-containing vacuoles. Cell Microbiol. 2007 Oct;9(10):2517-29. PubMed PMID: 17578517; PubMed Central PMCID: PMC2062534.

纯度：≥98%

CAS：175212-04-1