PC-190723 (PC190723) is a novel and potent antibacterial agent acting as an inhibitor of FtsZ with effectiveness against methicillin- and multi-drug-resistant Staphylococcus aureus. FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian I2-tubulin that polymerizes and assembles into a ring to initiate cell division. The continuous emergence and rapid spread of a multidrug-resistant strain of bacterial pathogens have demanded the discovery and development of new antibacterial agents. A highly conserved prokaryotic cell division protein FtsZ is considered as a promising target by inhibiting bacterial cytokinesis. Inhibition of FtsZ assembly restrains the cell-division complex known as divisome, which results in filamentation, leading to lysis of the cell.

纯度：≥98%

CAS：951120-33-5