CP 154,526 is a selective, non-peptide CRF1 receptor antagonist (Kis are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). CP 154,526 blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. References: García-Carmona JA, Camejo DM, Almela P, Jiménez A, Milanés MV, Sevilla F, Laorden ML. CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference. PLoS One. 2015 Aug 27;10(8):e0136164. doi: 10.1371/journal.pone.0136164. PubMed PMID: 26313266; PubMed Central PMCID: PMC4551807.

纯度：≥98%

CAS：157286-86-7