NSC745887 is an anticancer agent which traps DNA-topoisomerase cleavage and suppresses DcR3-associated signaling pathways. This causes apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade. References: Fann LY, Chen Y, Chu DC, Weng SJ, Chu HC, Wu ATH, Lee JF, Ali AAA, Chen TC, Huang HS, Ma KH. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. doi: 10.18632/oncotarget.23714. eCollection 2018 Feb 23. PubMed PMID: 29552282; PubMed Central PMCID: PMC5844718.

纯度：≥98%

CAS：54490-26-5