CP 339818 is novel, potent and non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM). Inhibits KV1.4 with an IC50 of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2. CP-339818 blocks both Kv1.3 and Kv1.4. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. Kv1.3 is expressed in the brain and in effector memory Tem (T) cells, and it is a member of the Shaker family of voltage-gated potassium channels.

纯度：≥98%

CAS：185855-91-8