CPI-7c is a unique small-molecule inhibitor of MDM2. CPI-7c inhibits MDM2-p53 interaction and promotes MDM2 degradation. CPI-7c binds to both RING and N-terminal domains of MDM2 to promote its ubiquitin-mediated degradation and p53 stabilization. References: Singh AK, Chauhan SS, Singh SK, Verma VV, Singh A, Arya RK, Maheshwari S, Akhtar MS, Sarkar J, Rangnekar VM, Chauhan PMS, Datta D. Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer. Carcinogenesis. 2016 Nov 1;37(11):1027-1040. doi: 10.1093/carcin/bgw088. PubMed PMID: 27543608.

纯度：≥98%

CAS：1613078-24-2