CGP36742 is the first orally bioavailable GABAB-selective antagonist. CGP 36742's IC50 for blocking GABAergic transmission is 36 μM. CGP36742 in rats blocks baclofen-induced neuronal depression, and reduces learning deficit and passive avoidance in an olfactory bulbectomy depression model. References: Nowak G, Partyka A, Palucha A, Szewczyk B, Wierońska JM, Dybala M, Metz M, Librowski T, Froestl W, Papp M, Pilc A. Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol. 2006 Nov;149(5):581-90. PubMed PMID: 16921399; PubMed Central PMCID: PMC2014666.

纯度：≥98%

CAS：123690-78-8