CS-526, formerly known as R-105266, is a proton pump inhibitor potentially for treatment of gastric ulcer. CS-526 has a potent antisecretory effect on gastric acid secretion without rebound gastric hypersecretion. The inhibitory mechanism of CS-526 on H+,K+-ATPase was a competitive antagonism to the K+ binding site of H+,K+-ATPase, and it was also a reversible inhibition. CS-526 inhibited acute gastric mucosal lesions. CS-526 inhibited histamine-stimulated gastric acid secretion in a dose- and retention time-dependent manner. References: De Luca L, Olivari Z, Farina A, Gonzini L, Lucci D, Di Chiara A, Casella G, Chiarella F, Boccanelli A, Di Pasquale G, De Servi S, Bovenzi FM, Gulizia MM, Savonitto S. Temporal trends in the epidemiology, management, and outcome of patients with cardiogenic shock complicating acute coronary syndromes. Eur J Heart Fail. 2015 Nov;17(11):1124-32. doi: 10.1002/ejhf.339. Epub 2015 Sep 4. PubMed PMID: 26339723.

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CAS：313272-12-7