YM-264 is a selective, potent and orally bioavailable platelet-activating factor antagonist potentially for the treatment of asthma. YM264 inhibited [3H] platelet-activating factor binding to rabbit platelet membranes with a pKi of 8.85. YM264 inhibited the platelet-activating factor-induced human, rabbit and guinea-pig platelet aggregation with pA2 values of 8.68, 8.33 and 8.14, respectively. ight in a parallel manner. References: Tsukumo Y, Harada D, Manabe H. Pharmacological characterization of itch-associated response induced by repeated application of oxazolone in mice. J Pharmacol Sci. 2010;113(3):255-62. PubMed PMID: 20595784.

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CAS：131888-54-5