CU-3, the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3, is a novel, potent and selective diacylglycerol kinase alpha (DGKalpha) inhibitor with an IC50 value of 0.6 μM, attenuating cancer cell proliferation and simultaneously enhancing immune responses including anti-cancer immunity. CU-3 competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells.

纯度：≥98%

CAS：861123-84-4