Cerulenin is an antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, blocking the interaction of malonyl-CoA. In sterol synthesis, cerulenin inhibits HMG-CoA synthetase activity. Inhibition of FAS by the irreversible (covalent) inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway. References: Tamura H, Okada H, Kume K, Koyano T, Goshima T, Nakamura R, Akao T, Shimoi H, Mizunuma M, Ohya Y, Hirata D. Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity. Biosci Biotechnol Biochem. 2015;79(7):1191-9. doi: 10.1080/09168451.2015.1020756. Epub 2015 Mar 19. PubMed PMID: 25787154.

纯度：≥98%

CAS：17397-89-6