Fadraciclib (CYC-065) is a novel, 2nd generation, ATP-competitive and orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9, IC50s of 5 and 26 nM for CDK2/9) with potential antineoplastic and chemoprotective activities. CYC065 selectively binds to and inhibits the activity of CDK2, 5 and 9, which leads to inhibition of CDK2, 5 and 9-dependent cellular pathways, downregulation of genes involved in the pro-survival pathway, prevention of the activation of DNA double-strand break repair pathways, and induction of both cell cycle arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing tumor cells. In addition, CYC065 protects hematopoietic stem and progenitor cells (HSPCs), prevents myelosuppression, and preserves the function of the bone marrow.

纯度：≥98%

CAS：1070790-89-4