Cycloserine is an analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. Cycloserine works as an antibiotic by inhibiting cell-wall biosynthesis in bacteria. As a cyclic analogue of D-alanine, cycloserine acts against two crucial enzymes important in the cytosolic stages of alanine racemase (Alr) and D-D-alanine ligase (Ddl). The first enzyme is a pyridoxal 5'-phosphate-dependent enzyme which converts the L-alanine to the D-alanine form. The second enzyme is involved in joining two of these D-alanine residues together by catalyzing the formation of the ATP-dependent D-alanine-D-alanine dipeptide bond between the resulting D-alanine molecules. References: Sartori SB, Maurer V, Murphy C, Schmuckermair C, Muigg P, Neumann ID, Whittle N, Singewald N. Combined neuropeptide S and D-cycloserine augmentation prevents the return of fear in extinction impaired rodents: advantage of dual vs. single drug approaches. Int J Neuropsychopharmacol. 2015 Dec 1. pii: pyv128. doi: 10.1093/ijnp/pyv128. [Epub ahead of print] PubMed PMID: 26625894.

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CAS：68-41-7