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CyPPA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:73029-73-9
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

CyPPA is a positive modulator of SK3 and SK2, which reduces the activity of dopaminergic neurons. CyPPA inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate. References: Herrik KF, Redrobe JP, Holst D, Hougaard C, Sandager-Nielsen K, Nielsen AN, Ji H, Holst NM, Rasmussen HB, Nielsen EO, Strobaek D, Shepard PD, Christophersen P. CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Front Pharmacol. 2012 Feb 13;3:11. doi: 10.3389/fphar.2012.00011. eCollection 2012. PubMed PMID: 22347859; PubMed Central PMCID: PMC3278045. 2: Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C. Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia. Glia. 2012 Dec;60(12):2050-64. doi: 10.1002/glia.22419. Epub 2012 Sep 21. PubMed PMID: 23002008; PubMed Central PMCID: PMC3799773.

纯度:≥98%

CAS:73029-73-9