Glipizide is a short-acting, second-generation, blood-glucose-lowering agent belonging to the sulfonylurea class that increases the release of endogenous insulin from β-cells by blocking potassium channels. The drug-formulated version of Glipizide, marketed as Glucotrol or under generic label, is most commonly prescribed to lower blood sugar levels in type 2 diabetes. Glipizide is rapidly absorbed, has a very quick onset of action and a short half-life. This agent is extensively metabolized in the liver and the metabolites as well as the unchanged form are excreted in the urine. References: Adeshara K, Tupe R. Antiglycation and cell protective actions of metformin and glipizide in erythrocytes and monocytes. Mol Biol Rep. 2016 Mar;43(3):195-205. doi: 10.1007/s11033-016-3947-5. Epub 2016 Feb 13. PubMed PMID: 26874852.

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CAS：29094-61-9