Dacomitinib metabolite M2 is the cysteine conjugated metabolite of Dacomitinib. Dacomitinib (aslo known as PF299804, PF299; trade name: Vizimpro) is a novel, potent, orally bioavailable, highly selective, irreversible, second generation pan-ErbB inhibitor, mostly to EGFR with with IC50 of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively in cell-free assays. It has potential antineoplastic activit and is effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. As of Sep 29 2018, Dacomitinib has been approved by FDA as first-line agent for the treatment of NSCLC.

纯度：≥98%

CAS：1262034-38-7