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Dacomitinib metabolite M2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dacomitinib metabolite M2图片
CAS NO:1262034-38-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

Dacomitinib metabolite M2 is the cysteine conjugated metabolite of Dacomitinib. Dacomitinib (aslo known as PF299804, PF299; trade name: Vizimpro) is a novel, potent, orally bioavailable, highly selective, irreversible, second generation pan-ErbB inhibitor, mostly to EGFR with with IC50 of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively in cell-free assays. It has potential antineoplastic activit and is effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. As of Sep 29 2018, Dacomitinib has been approved by FDA as first-line agent for the treatment of NSCLC.

纯度:≥98%

CAS:1262034-38-7