Piragliatin (RO4389620; RO-4389620) is a novel and potent glucokinase activator (gka) with anti-diabetic activities. It enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus. Piragliatin has an acute glucose-lowering action in patients with mild type 2 diabetes, mainly mediated through a generalized enhancement of β-cell function and through fasting restricted changes in glucose turnover.

纯度：≥98%

CAS：625114-41-2