CC618 is a potent and selective PPARβ/δ antagonist. CC618 selectively antagonizes agonist-induced PPARβ/δ activity with an IC50 = 10.0 μM. The treatment of PPARβ/δ with CC618 leads to a covalent modification of Cys249, located centrally in the PPARβ/δ ligand binding pocket, corresponding to the conversion of its thiol moiety to a 5-trifluoromethyl-2-pyridylthioether. References: Kaupang A, Kase ET, Vo CX, Amundsen M, Vik A, Hansen TV. Synthesis of 5-trifluoromethyl-2-sulfonylpyridine PPARβ/δ antagonists: Effects on the affinity and selectivity towards PPARβ/δ. Bioorg Med Chem. 2015 Dec 10. pii: S0968-0896(15)30177-2. doi: 10.1016/j.bmc.2015.12.012. [Epub ahead of print] PubMed PMID: 26707845.

纯度：≥98%

CAS：1680204-90-3