DCZ3301 is an aryl-guanidino inhibitor that induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma. DCZ3301 induces G2/M cell cycle arrest, and associates with downregulation of CDK1, cyclin B1, and cdc25C. DCZ3301 also induces cell apoptosis by decreasing MMP in T-cell leukemia/lymphoma cells. References: Xiao W, Li B, Sun X, Yu D, Xie Y, Wu H, Chang S, Zhou Y, Wang H, Lan X, Xu Z, Shi J, Zhu W. DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma. Acta Biochim Biophys Sin (Shanghai). 2018 Jul 1;50(7):643-650. doi: 10.1093/abbs/gmy047. PubMed PMID: 29688264.

纯度：≥98%

CAS：2136278-38-9